Nothing is Working!

I am ready to throw my computer across the room. No matter what I try, I just cannot seem to get a faster startup. The thing takes about eight minutes just to get fully loaded and ready for me to use. It is running slow in everything else, too. I have defragmented, did a virus scan, removed some spyware, disabled some startup programs, and cleaned the registry. I am at a complete loss. It seems like I might have to format my hard drive. I have never formatted and reinstalled before so I do not even know where to begin. I need help!

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